Vinay Varadan, PhD
Dr. Vinay Varadan is an Assistant Professor in the Department of General Medical Sciences-Oncology within the School of Medicine at Case Western Research University. As a member of Case Comprehensive Cancer Center, the overarching theme of Dr. Varadan's translational research is to discover novel biomarkers and therapeutic targets through integrative analysis of large-scale molecular profiling datasets derived from retrospective and clinical trial cohorts, coupled with functional genomic screens. Thus, his research interests span statistical signal processing, machine learning, big data analytics, computational systems biology, functional genomics and genomics-enabled clinical trial development.
Postdoctoral ResearchersSirvan Khalighi, PhD
Dr. Sirvan Khalighi works on developing multi-scale models to infer the functional impact of cellular aberrations in cancer. He received M.Sc. and Ph.D. degrees in artificial intelligence and robotics from Sharif University of Technology, Iran, 2005 and University of Coimbra, Portugal, 2016, respectively. He was a researcher at the Institute for Systems and Robotics (ISR-UC) where he has been involved with projects in the area of automatic sleep staging and brain computer interfaces. His research interests include computational systems biology, biomedical signal processing, statistical pattern recognition, transfer learning, and domain adaptation with healthcare applications.
K Ramachandra Murthy, PhD
Dr. K Ramachandra Murthy is currently developing computational methods to model complex signaling networks in individual tumors with applications in drug repositioning and adaptive trial design. He received an M.Sc. in Mathematics from University of Hyderabad, India followed by M.Tech. and Ph.D. in Computer Science from Indian Statistical Institute (ISI), Kolkata, India. He was senior research fellow and research associate at the Machine Intelligence Unit, ISI. He also worked as a postdoctoral fellow at the Institute for Development and Research in Banking Technology, Hyderabad, India, focusing on scalability issues of dimensionality reduction methodologies applied to big data analytics. His research interests include machine learning, pattern recognition, big data analytics, dimensionality reduction, convex optimization, computational systems biology and functional genomics.
Research StaffSalendra Singh, MS
Salendra Singh is the Lead Bioinformatics Analyst/Programmer in the Varadan Laboratory. His interests span next-generation sequencing analysis, pan-cancer analytics and large-scale molecular integration in addition to big data analytics platform development and visualization.
Graduate StudentsJaspreet Kaur
Jaspreet Kaur is a graduate student at Case Western Reserve University pursuing a Masters in Systems Biology and Bioinformatics. She is interested in identifying the molecular underpinnings of Triple Negative Breast Cancer using integrative analyses of genome-scale tumor molecular profiles.
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We are a growing collaborative team of engineers, biologists, programmers and scientists dedicated to solving some of the most complex problems in translational cancer research through the integration of innovative data science with deep biological knowledge.
Our ongoing collaborations within the Cancer Center and beyond span the translational spectrum, from clinicians to engineers and molecular biologists, thus allowing us to traverse the journey from bedside-to-computer-to-bench and then back-to-bedside.
Alumni
1) Abolfazl Razi, PhD (Postdoctoral Fellow) - Currently Asst. Prof. @ Northern Arizona University, AZ
2) Anna Keri (Young Scientist Foundation - Summer Intern) - Undergraduate program @ Washington University in St. Louis
Our ongoing collaborations within the Cancer Center and beyond span the translational spectrum, from clinicians to engineers and molecular biologists, thus allowing us to traverse the journey from bedside-to-computer-to-bench and then back-to-bedside.
Alumni
1) Abolfazl Razi, PhD (Postdoctoral Fellow) - Currently Asst. Prof. @ Northern Arizona University, AZ
2) Anna Keri (Young Scientist Foundation - Summer Intern) - Undergraduate program @ Washington University in St. Louis