InFlo: An integrative systems biology framework for characterizing activities of complex signaling networks in individual patient samples using multi-omics profiling
- InFlo is a novel systems biology approach for characterizing the activities of complex signaling networks using a unique multidimensional framework integrating transcriptomic, genomic and/or epigenomic profiles for any given biological sample.
- InFlo integrates diverse sources of molecular profiles and robustly characterizes tissue-specific differences in activities of signaling networks on a genome scale using unique probabilistic models of molecular interactions on a per-sample basis.
- A unique feature of InFlo is that it specifically accounts for potential inconsistencies between curated signaling networkdefinitions and the wiring of the pathway in the specific tissue context
InFlo: a novel systems biology framework identifies cAMP-CREB1 axis as a key modulator of platinum resistance in ovarian cancer
N Dimitrova(1), A B Nagaraj(2), A Razi(2), S Singh(2), S Kamalakaran(1), N Banerjee(1), P Joseph(2), A Mankovich(1), P Mittal(3,4), A DiFeo(2,4) and V Varadan(2,4)
Oncogene advance online publication 7 November 2016;doi: 10.1038/onc.2016.398
N Dimitrova(1), A B Nagaraj(2), A Razi(2), S Singh(2), S Kamalakaran(1), N Banerjee(1), P Joseph(2), A Mankovich(1), P Mittal(3,4), A DiFeo(2,4) and V Varadan(2,4)
Oncogene advance online publication 7 November 2016;doi: 10.1038/onc.2016.398
PAN-CANCER ANALYSES
TCGA-PROJECT |
CANCER |
SAMPLES |
STATUS |
Bladder Urothelial Carcinoma |
406 |
Processed |
|
Breast Invasive Carcinoma |
1072 |
Processed |
|
Cholangiocarcinoma |
36 |
Processed |
|
Glioblastoma Multiforme |
139 |
Processed |
|
Kidney Chromophobe |
66 |
Processed |
|
Kidney Renal Clear Cell Carcinoma |
525 |
Processed |
|
Kidney Renal Papillary Cell Carcinoma |
529 |
Processed |
|
Liver Hepatocellular Carcinoma |
362 |
Processed |
|
Lung adenocarcinoma |
510 |
Processed |
|
Lung Squamous Cell Carcinoma |
498 |
Processed |
|
Ovarian Serous Cystadenocarcinoma |
357 |
Processed |
|
Pheochromocytoma and Paraganglioma |
172 |
Processed |
|
Prostate Adenocarcinoma |
477 |
Processed |
|
Thyroid Carcinoma |
497 |
Processed |
|
ALL CANCERS |
TOTAL SAMPLES |
5284 |
Processed |