InFlo: An integrative systems biology framework for characterizing activities of complex signaling networks in individual patient samples using multi-omics profiling
  • InFlo is a novel systems biology approach for characterizing the activities of complex signaling networks using a unique multidimensional framework integrating transcriptomic, genomic and/or epigenomic profiles for any given biological sample.
  • InFlo integrates diverse sources of molecular profiles and robustly characterizes tissue-specific differences in activities of signaling networks on a genome scale using unique probabilistic models of molecular interactions on a per-sample basis.
  • A unique feature of InFlo is that it specifically accounts for potential inconsistencies between curated signaling networkdefinitions and the wiring of the pathway in the specific tissue context
InFlo: a novel systems biology framework identifies cAMP-CREB1 axis as a key modulator of platinum resistance in ovarian cancer
N Dimitrova(1), A B Nagaraj(2), A Razi(2), S Singh(2), S Kamalakaran(1), N Banerjee(1), P Joseph(2), A Mankovich(1), P Mittal(3,4), A DiFeo(2,4) and V Varadan(2,4)
Oncogene advance online publication 7 November 2016;doi: 10.1038/onc.2016.398

PAN-CANCER ANALYSES

TCGA-PROJECT
CANCER
SAMPLES
STATUS
TCGA-BLCA
Bladder Urothelial Carcinoma
406
Processed
TCGA-BRCA
Breast Invasive Carcinoma
1072
Processed
TCGA-CHOL
Cholangiocarcinoma
36
Processed
TCGA-GBM
Glioblastoma Multiforme
139
Processed
​​TCGA-KICH
Kidney Chromophobe
66
Processed
​TCGA-KIRC
Kidney Renal Clear Cell Carcinoma
525
​Processed
TCGA-KIRP
Kidney Renal Papillary Cell Carcinoma
529
Processed
TCGA-LIHC
Liver Hepatocellular Carcinoma
​362
Processed
​TCGA-LUAD
​Lung adenocarcinoma
510
Processed
TCGA-LUSC
​​​Lung Squamous Cell Carcinoma
498
Processed
​TCGA-OV
Ovarian Serous Cystadenocarcinoma
357
Processed
​​TCGA-PCPG
Pheochromocytoma and Paraganglioma
172
Processed
​TCGA-PRAD
​Prostate Adenocarcinoma
477
Processed
​TCGA-THCA
Thyroid Carcinoma
497
Processed
ALL CANCERS
TOTAL SAMPLES
5284
Processed